Helping patients know more, and helping researchers reach them sooner.
What started as our family's rare disease journey led us to build an AI Patient Intelligence Engine and a community of 1M+ patients and caregivers worldwide, connected to new research and support. Today it helps research teams reach the people their studies are for.
Who we work with: pharma and biotech sponsors, CROs, study sites, and teams running observational and real-world studies.
Three AI systems that close the knowledge gaps, from a patient's first search to study enrollment and beyond.
Reach patients when they're looking for answers.
HealthSignal creates helpful condition pages and learns which ones best answer what people search for, so patients find relevant studies and support.
Winner auto-promoted · +152% lift
A private health journal patients keep for themselves.
AI-guided check-ins help people track symptoms, treatments and quality of life. Patients who choose to can contribute their entries to research, combined and de-identified.
How have your headaches been this week?
Still pretty bad. Worst in the mornings, and bright light makes them worse.
Symptom entry · Headaches · morning onset, light trigger noted
Understand patient needs through shared experiences.
Combined, de-identified insights from patients who opt in help shape better study protocols, support programs and treatments.
Aggregated, de-identified · opted-in patients only
Integrated AI patient intelligence programs supporting recruitment, medical strategy, and treatment launch.
Accelerate recruitment
Understand patient experiences
Help patients learn about and access new treatments
Condition communities, stories and HealthSignal pages meet patients and caregivers where they're already searching.
HealthSpark and plain-language study information help people understand what taking part involves.
Patients who want to explore a study get eligibility pre-screening and, where offered, a conversation with our nurse team.
With the patient's permission, we refer them to the study site and keep supporting them through to enrollment.
Rare disease communities are small and close-knit, and their trust is what makes recruitment work. Every Know Rare program runs on separate, specific opt-ins that patients can change at any time. Nothing is required to use Know Rare.
We connect a patient with a study, and share their details with that study team only when they ask us to.
Patients can opt in to contribute to pharma research and observational studies.
Patients can opt in separately to help drug companies with commercial planning.
See how pharma and biotech teams have used Know Rare's AI Patient Intelligence Engine to accelerate recruitment and generate real-world evidence.
Our therapeutic coverage spans gene therapy, rare metabolics, cancer, dermatology, autoimmune, hematology, heart and kidney, and neurology, and a community of 1M+ patients and caregivers worldwide. HealthSignal communities cover all 6,000+ conditions in the NIH Genetic and Rare Diseases Information Center.
For recruitment, referrals of patients who asked to be connected with your specific study; their details are shared only at their request. For research and commercial programs, aggregated, de-identified insights drawn only from patients who opted in. We don't sell individual patient records.
Know Rare is ISO/IEC 27001:2022 certified. Shared insights are aggregated and de-identified with minimum group sizes, so small rare-disease cohorts can't be traced back to individuals, and partner contracts prohibit re-identification or contacting patients from the data.
That's where we started. In one rare pediatric trial that had gone 2 years without enrolling a patient, Know Rare found the first patients in under a month and 98% of referred patients were randomized.
Schedule a meeting below. We'll talk through your indication, study or program goals and timelines, and recommend the right program.
See how rare disease intelligence can move your program forward.
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