Living with Type II complement component 8 deficiency
An inherited immune condition that makes repeated meningococcal and related infections more likely.
Understanding Type II complement component 8 deficiency
People with C8 deficiency have repeated infections with Neisseria bacteria, mainly meningococcus. Many are found after a first episode of meningitis after age 10. In type II, the C8 beta part is deficient. Type I and type II look the same clinically.
Signs & symptoms
GARD doesn't list a separate symptom list. The summary describes these features:
- Repeated infections with Neisseria bacteria
- Meningococcal infections
- Often a first episode of meningitis after age 10
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with rare disease patient organizations for support
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says it is autosomal recessive, so a child inherits a changed copy of a gene from each parent. In type II, only the C8 beta protein is deficient.
Also known as: c8 beta deficiency; c8 deficiency, type ii; c8b classic complement early component deficiency; c8b deficiency; classic complement early component deficiency caused by mutation in c8b; complement c8 deficiency, type ii
Patient organizations
Rare-disease groups that can help
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Type II complement component 8 deficiency.
Explore research for Type II complement component 8 deficiency
Explore actively recruiting Type II complement component 8 deficiency studies with HealthSpark.
Find actively recruiting studies for Type II complement component 8 deficiency with HealthSpark. Share your city to explore research near you.
- Recruiting studies from ClinicalTrials.gov
- Share your city to look for research near you
- Eligibility is confirmed by the study team
Powered by HealthSpark, our AI chat helper
I can help you find recruiting Type II complement component 8 deficiency studies. Enter a ZIP code, address or city below and I'll look within 50 miles.
Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
Get Signals for Type II complement component 8 deficiency
Stay in the loop with community stories and updates from medical researchers.
Create a living journal that talks back
HealthStory evolves private journaling with a living AI journal that talks back and asks thoughtful questions, helping you capture your Type II complement component 8 deficiency experiences more deeply and prepare for better conversations with your doctors and care team.
Your journal is private. Sharing your story publicly is a separate choice, made with Share your story above.