Living with Transient hypogammaglobulinemia of infancy
A temporary delay in a young child's antibody production that can cause repeated infections in the first few years.
Understanding Transient hypogammaglobulinemia of infancy
The immune system is slow to mature its antibody (immunoglobulin) production. Children may have repeated breathing infections, ear infections, bronchitis, stomach illness, or allergy symptoms in the first two to four years, and then it resolves on its own. Some children have no symptoms. GARD says severe infections are rare, and the ability to make antibodies after vaccines is usually normal.
Signs & symptoms
Symptoms vary from person to person. GARD lists these as possible features:
- Repeated respiratory infections
- Ear infections (otitis media)
- Bronchitis
- Stomach illness (gastroenteritis)
- Allergy symptoms
- No symptoms in some children
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include allergy and immune system specialists and genetic specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in genes (variants) cause this condition, but it doesn't name a specific gene. It describes a delay in how antibody production matures.
Also known as: immunoglobulin maturational delay; newborn gammaglobulin deficiency; thi; thi - transient hypogammaglobulinemia of infancy
Patient organizations
- Immune Deficiency FoundationPrimary immunodeficiency · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Transient hypogammaglobulinemia of infancy.
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