Living with Transgrediens et progrediens palmoplantar keratoderma
A rare skin condition with thick, red-yellow skin on the palms and soles that spreads and gets worse with age.
Understanding Transgrediens et progrediens palmoplantar keratoderma
The thick skin spreads to the backs of the hands and feet, wrists, and the skin over the Achilles tendon. It gradually worsens with age and can spread to the shins, knees, and elbows. Heavy sweating usually goes along with it. It starts in childhood.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Thick skin on the palms and soles
- Heavy sweating (hyperhidrosis)
- Poorly formed fingernails and toenails
- Repeated bacterial or fungal skin infections
- Fingers that cannot fully straighten
- Cracks at the corners of the mouth
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Foundation for Ichthyosis and Related Skin Types may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: Foundation for Ichthyosis and Related Skin Types
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Foundation for Ichthyosis and Related Skin Types and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in genes (variants) cause this condition, but it doesn't name a specific gene.
Also known as: greither disease; keratosis extremitatum hereditaria progrediens; keratosis palmoplantaris transgrediens et progrediens; progressive diffuse palmoplantar keratoderma; progressive diffuse ppk; transgrediens et progrediens ppk
Patient organizations
- Foundation for Ichthyosis and Related Skin TypesTransgrediens et progrediens palmoplantar keratoderma · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Transgrediens et progrediens palmoplantar keratoderma.
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