Living with T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta
A rare inherited immune condition with no T cells, causing repeated infections starting in infancy or early childhood.
Understanding T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta
People lack T cells but have B cells and natural killer (NK) cells. They get repeated infections in infancy or early childhood. How severe it is varies with the underlying gene change. Treatment with a bone marrow transplant is mentioned by GARD.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Repeated infections
- Fever
- Slow weight gain from infections
- Low T cell count
- Low lymphocyte count
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include allergy and immune system specialists and genetic specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in genes (variants) cause this condition. It is autosomal recessive, meaning a child inherits a changed copy of a gene from each parent. GARD doesn't list the gene here.
Also known as: t-b+ scid due to cd3delta/cd3epsilon/cd3zeta
Patient organizations
- Immune Deficiency FoundationPrimary immunodeficiency · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta.
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