Living with Striate palmoplantar keratoderma
An inherited skin condition with painful, thick skin in lines on the palms and soles.
Understanding Striate palmoplantar keratoderma
Thick skin forms in lines along the fingers and palms and in patches on the soles. The thickened skin can be painful and may crack, blister, or sweat heavily. Rarely, thick skin forms on the knees or the backs of the fingers and toes. Signs may begin in the newborn or infant years.
Signs & symptoms
Symptoms vary from person to person. GARD lists these:
- Thick skin on palms and soles
- Lines of thick skin along the fingers
- Pain in thickened skin
- Cracking or blistering skin
- Heavy sweating
- Hair or nail differences
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Foundation for Ichthyosis and Related Skin Types may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: Foundation for Ichthyosis and Related Skin Types
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Foundation for Ichthyosis and Related Skin Types and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in genes (variants) cause this condition. It is autosomal dominant, meaning one changed copy of a gene can cause it. GARD doesn't list which gene.
Also known as: keratosis palmoplantaris striata; keratosis palmoplantaris striata et areata; keratosis palmoplantaris varians of wachters
Patient organizations
- Foundation for Ichthyosis and Related Skin TypesStriate palmoplantar keratoderma · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Striate palmoplantar keratoderma.
Explore research for Striate palmoplantar keratoderma
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- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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