Living with Striatal degeneration, autosomal dominant
An inherited movement condition that starts in adulthood, with slow movements, muscle stiffness, and speech trouble.
Understanding Striatal degeneration, autosomal dominant
It causes slow movements (bradykinesia), slurred or hard-to-form speech (dysarthria), and muscle stiffness. It affects a part of the brain that helps control movement, called the striatum. Signs usually begin in adulthood.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Slow movements
- Muscle stiffness (rigidity)
- Slurred or hard-to-form speech
- Trouble with quick, alternating movements
- Trouble walking
- Trouble swallowing
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include brain and nervous system specialists and genetic specialists.
- 3Consider genetic testing
Changes in PDE8B are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Parkinson & Movement Disorder Alliance may keep lists of experts for this condition.
Care & treatment
- Care team
- Brain and nervous system specialists (neurologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Parkinson & Movement Disorder Alliance
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Parkinson & Movement Disorder Alliance
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the PDE8B gene cause this condition. It is autosomal dominant, meaning one changed copy of the gene can cause it.
Also known as: adsd; autosomal dominant striatal neurodegeneration
Patient organizations
- Parkinson & Movement Disorder AllianceParkinsonism · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Striatal degeneration, autosomal dominant.
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