Living with Spermatogenic failure 9
A genetic condition in males in which the sperm have round heads and can't fertilize an egg.
Understanding Spermatogenic failure 9
Normal sperm have an oval head with a cap called the acrosome, which holds enzymes that help the sperm enter an egg. In globozoospermia, sperm have a round head and no acrosome. They can't fertilize an egg, which leads to infertility.
Signs & symptoms
GARD lists these among the most common features:
- Sperm with round heads (globozoospermia)
- Male infertility
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with rare disease patient organizations for support
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD doesn't list a gene. A child inherits a changed copy of a gene from each parent (autosomal recessive).
Also known as: azoospermia caused by mutation in dpy19l2; dpy19l2 azoospermia; globozoospermia, complete; globozoospermia, total; spermatogenic failure type 9; spgf9
Patient organizations
Rare-disease groups that can help
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Spermatogenic failure 9.
Explore research for Spermatogenic failure 9
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- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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