Living with Seborrhea-like dermatitis with psoriasiform elements
A rare inherited skin condition causing a scaly red rash on the face and scalp and thick skin on the joints, hands, and feet.
Understanding Seborrhea-like dermatitis with psoriasiform elements
The rash is fine and scaly. It appears mostly on the face (chin, folds beside the nose, eyebrows), around the earlobes, and on the scalp. Skin also thickens over the elbows, knees, palms, soles, and knuckles. Cold weather, emotional stress, and hard exercise can make it worse. It starts in childhood.
Signs & symptoms
GARD doesn't list specific symptoms for this condition. Its summary describes these:
- Scaly red rash on the face and scalp
- Thickened skin on elbows and knees
- Thick skin on palms and soles
- Thick skin over the knuckles
- Symptoms worse with cold, stress, or hard exercise
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in ZNF750 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Children's Skin Disease Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by changes in the ZNF750 gene. It is autosomal dominant, so one changed copy of the gene can be enough.
Patient organizations
- Children's Skin Disease FoundationSkin diseases · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Seborrhea-like dermatitis with psoriasiform elements.
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