Living with Recurrent infections associated with rare immunoglobulin isotypes deficiency
Immune conditions with low levels of certain antibody types, often causing repeated sinus and lung infections.
Understanding Recurrent infections associated with rare immunoglobulin isotypes deficiency
They include IgG subclass deficiency, IgG subclass deficiency with IgA deficiency, and kappa chain deficiency. Many people have no symptoms, but some have repeated sinus and lung infections, often with pus-forming bacteria. GARD lists onset in childhood.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Repeated bacterial infections
- Repeated chest infections
- Repeated colds and sinus infections
- Asthma
- Autoimmune problems
- Severe infections in some people
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include allergy and immune system specialists and genetic specialists.
- 3Consider genetic testing
Changes in IGKC are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
This condition is caused by changes in the IGKC gene. A child inherits a changed copy of the gene from each parent (autosomal recessive).
Also known as: igg subclass deficiency with iga subclass deficiency; isolated igg subclass deficiency; kappa chain deficiency; kappa-chain deficiency
Patient organizations
- Immune Deficiency FoundationPrimary immunodeficiency · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Recurrent infections associated with rare immunoglobulin isotypes deficiency.
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