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Living with Reactive arthritis

Joint inflammation that develops as a reaction to an infection elsewhere in the body, sometimes with eye or urinary symptoms.

Understanding Reactive arthritis

Reactive arthritis is a type of arthritis that happens as a reaction to an infection elsewhere in the body.

It may appear weeks or even months after the infection has cleared. Along with joint inflammation, it can cause red, inflamed eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These may occur alone, together, or not at all.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Joint pain, swelling, and stiffness
  • Low back pain
  • Red, irritated eyes (conjunctivitis)
  • Inflammation where tendons attach to bone (enthesitis)
  • Abdominal pain or diarrhea
  • Nail or skin changes

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include autoimmune and inflammatory disease specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Autoimmune Association, Global Autoimmune Institute and Spondylitis Association of America may keep lists of experts for this condition.

Care & treatment

Care team
autoimmune and inflammatory disease specialists (rheumatologists)
Expert care
Expert lists: Autoimmune Association, Global Autoimmune Institute, Spondylitis Association of America
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Autoimmune Association and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which infection triggered my arthritis?
Should I be tested for HLA-B27?
Which treatments can ease my joint and eye symptoms?

Quick facts

Symptoms usually starta variety of ages

GARD says the exact cause isn't known. It may follow infection with bacteria like Salmonella, Yersinia, Campylobacter, Shigella, or Chlamydia trachomatis. Certain genes, such as HLA-B27, may raise the chance of it.

Also known as: arthritis occurring after infection; arthritis urethritica; fiessinger-leroy disease; polyarthritis enterica; post-bacterial arthropathy; post-infective arthritis

Patient organizations

Source: NIH GARD · Reactive arthritisGARD ID 5693 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Reactive arthritis.

Explore the Reactive arthritis blog

Explore research for Reactive arthritis

Explore actively recruiting Reactive arthritis studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Reactive arthritis with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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