Living with Pyogenic bacterial infections due to MyD88 deficiency
A rare inherited immune condition that causes frequent, severe pus-forming bacterial infections in early childhood.
Understanding Pyogenic bacterial infections due to MyD88 deficiency
It affects the innate immune response, the body's early, general response to germs. Resistance to other bacteria, viruses, fungi, and parasites is normal. Most people have a first infection before age 2, and infections become less frequent by about age 10. Many people don't develop a high fever at first, even when an infection is severe.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Abscesses (pockets of pus)
- Repeated meningitis
- Late falling-off of the umbilical cord
- Blood infections (septicemia)
- Infected joints (septic arthritis)
- Ear, nose, and throat infections
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says it is inherited in an autosomal recessive way, meaning a child inherits a changed copy of the gene from each parent. It doesn't name a gene here, but the condition involves the MyD88 protein.
Also known as: imd68; immunodeficiency 68; myd88 deficiency; myd88d; pyogenic bacterial infection due to deficiency of myeloid differentiation primary response 88; pyogenic bacterial infection due to myd88 deficiency
Patient organizations
- Immune Deficiency FoundationPyogenic bacterial infections due to MyD88 deficiency · United States
- Jeffrey Modell FoundationPyogenic bacterial infections due to MyD88 deficiency · United States
You are more than your diagnosis
Perspectives from people navigating life with Pyogenic bacterial infections due to MyD88 deficiency.
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