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Living with Pruritic urticarial papules and plaques of pregnancy

An itchy pregnancy rash, usually in the third trimester of a first pregnancy, that goes away within weeks.

Understanding Pruritic urticarial papules and plaques of pregnancy

Pruritic urticarial papules and plaques of pregnancy (PUPPP) is a rare skin condition that causes very itchy bumps and patches during pregnancy.

It mainly affects the belly, buttocks, and upper thighs. It usually starts in the third trimester of a first pregnancy, though it can start after delivery. The symptoms generally clear up within a few weeks.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Severe itching (pruritus)
  • Red bumps (papules)
  • Raised hive-like patches (plaques)
  • Itching on the belly
  • Small skin blisters
  • Stretch marks

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include allergy and immune system specialists, maternal-fetal medicine specialists, skin, hair, and nail specialists and women’s reproductive health specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Allergy and immune system specialists (allergists / immunologists); Maternal-fetal medicine specialists (pregnancy-related); Skin, hair, and nail specialists (dermatologists); Women’s reproductive health specialists (obstetricians / gynecologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Children's Skin Disease Foundation
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
What can ease the itching safely during pregnancy?
How long should the rash last?
Is it likely to come back in a later pregnancy?

Quick facts

Symptoms usually startTeenager and as an Adult
InheritanceAutosomal Dominant

GARD doesn't describe a cause for this condition yet. It lists autosomal dominant inheritance.

SkinUrinary and Reproductive

Also known as: pep - polymorphic eruption of pregnancy; polymorphic eruption of pregnancy; puppp; puppp - pruritic urticarial papules and plaques of pregnancy

Patient organizations

Broader rare-disease groups

Source: NIH GARD · Pruritic urticarial papules and plaques of pregnancyGARD ID 9635 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Pruritic urticarial papules and plaques of pregnancy.

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