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Living with Prinzmetal angina

A type of chest pain that comes on at rest, usually between midnight and early morning, caused by spasms in the heart's arteries.

Understanding Prinzmetal angina

Prinzmetal angina, also called Prinzmetal's variant angina (PVA), is a condition of repeated episodes of chest pain that usually occur at rest.

Episodes usually occur between midnight and early morning, unlike typical angina, which is often triggered by exertion or stress. They can last from several minutes to thirty minutes and be very painful. Pain can spread to the head, shoulder or arm. It is caused by spasms in the arteries that supply the heart muscle, which block blood flow.

Signs & symptoms

GARD describes these features:

  • Chest pain at rest
  • Episodes between midnight and early morning
  • Pain lasting several minutes up to thirty minutes
  • Pain that spreads to the head, shoulder or arm

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Your doctor may refer you to a specialist who knows rare conditions.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
A doctor familiar with rare conditions, plus specialists as needed
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with International Heart Spasms Alliance
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which tests, such as an ECG or angiogram, confirm the diagnosis?
What triggers should I try to avoid?
Which medicines can help prevent the spasms?

Quick facts

GARD says it is caused by spasms of the coronary arteries. It is most common in people who smoke or have high cholesterol or high blood pressure, and often occurs for unknown reasons in otherwise healthy people. Triggers can include alcohol withdrawal, stress, cold, certain medicines and stimulants like cocaine.

Also known as: angina inversa; angina pectoris, variant; coronary artery spasm angina; prinzmetal's angina; prinzmetal's variant angina; variant angina

Patient organizations

Source: NIH GARD · Prinzmetal anginaGARD ID 7465 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Prinzmetal angina.

Explore the Prinzmetal angina blog

Explore research for Prinzmetal angina

Explore actively recruiting Prinzmetal angina studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Prinzmetal angina with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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