Living with Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
A rare inherited immune condition that makes people very vulnerable to viral infections, including after live virus vaccines like MMR.
Understanding Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
People are especially likely to have problems with viral infections, particularly after live virus vaccines such as the MMR vaccine. Serious viral illness can include inflammation of the brain, liver or lungs. It starts in infancy.
Signs & symptoms
Symptoms vary from person to person. GARD lists these:
- Severe viral infections
- Low lymphocyte count
- Illness after live vaccines like MMR
- Brain inflammation (encephalopathy) in some
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include allergy and immune system specialists and genetic specialists.
- 3Consider genetic testing
Changes in STAT2 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the STAT2 gene cause this condition. It is autosomal recessive, meaning a child inherits a changed copy of the gene from each parent.
Also known as: imd44; immunodeficiency 44; immunodeficiency type 44; primary immunodeficiency with post-mmr vaccine viral infection
Patient organizations
- Immune Deficiency FoundationPrimary immunodeficiency · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection.
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