Living with Primary failure of tooth eruption
A rare genetic condition in which permanent teeth do not come in, even with nothing blocking them, mainly the back teeth.
Understanding Primary failure of tooth eruption
The back teeth are most often affected, and all teeth behind the first affected one are usually involved. This leaves a gap between upper and lower back teeth (posterior open bite). Teeth that haven't come in tend to become fused to the bone (ankylosed). GARD says orthodontic treatment of affected teeth is generally unsuccessful.
Signs & symptoms
GARD describes these signs:
- Permanent teeth that don't come in
- Back teeth most affected
- Gap between upper and lower back teeth (open bite)
- Teeth that fuse to the bone
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and gum, teeth and mouth specialists.
- 3Consider genetic testing
Changes in PTH1R are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
Care & treatment
- Care team
- Genetic specialists (geneticists); Gum, teeth and mouth specialists (odontologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with rare disease patient organizations for support
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the PTH1R gene cause this condition. It is autosomal dominant, meaning one changed copy of the gene is enough.
Also known as: dental noneruption; pfe; pfe - primary failure of tooth eruption; posterior openbite malocclusion, familial; primary retention of teeth; unerupted second primary molar
Patient organizations
Rare-disease groups that can help
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Primary failure of tooth eruption.
Explore research for Primary failure of tooth eruption
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