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Living with Plasmablastic lymphoma

An aggressive type of non-Hodgkin lymphoma that most often starts in the mouth but can affect other body areas.

Understanding Plasmablastic lymphoma

Plasmablastic lymphoma is an aggressive form of non-Hodgkin lymphoma.

It most commonly occurs in the mouth. It can also be found in the digestive tract, lymph nodes and skin. GARD says it is often linked to a weakened immune system, such as with HIV infection or immune-suppressing treatment.

Signs & symptoms

GARD doesn't list specific symptoms for this condition yet.

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include blood and bone marrow specialists and cancer specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Blood and bone marrow specialists (hematologists); Cancer specialists (oncologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Blood Cancer United and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Where is the lymphoma located, and how far has it spread?
What treatment options are available for me?
How does my immune health affect my care?

Quick facts

GARD says the exact cause is poorly understood. It is often associated with a suppressed immune system, such as HIV infection or immunosuppressive therapy.

Blood

Also known as: pbl

Patient organizations

Source: NIH GARD · Plasmablastic lymphomaGARD ID 12125 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Plasmablastic lymphoma.

Explore the Plasmablastic lymphoma blog

Explore research for Plasmablastic lymphoma

Explore actively recruiting Plasmablastic lymphoma studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Plasmablastic lymphoma with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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I can help you find recruiting Plasmablastic lymphoma studies. Enter a ZIP code, address or city below and I'll look within 50 miles.

Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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