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Living with Plague

A severe bacterial infection that can cause fever, chills, swollen lymph nodes and other symptoms.

Understanding Plague

Plague is a severe bacterial infection caused by the bacterium Yersinia pestis.

GARD describes it as an infection that can affect people at any time in life. It can cause a wide range of symptoms, including fever, chills, headache and swollen lymph nodes. Other symptoms may involve the skin, chest, liver and spleen.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Fever and chills
  • Headache
  • Tiredness (fatigue)
  • Swollen, inflamed lymph nodes
  • Chest pain and fast heart rate
  • Skin sores or blisters

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Your doctor may refer you to a specialist who knows rare conditions.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
A doctor familiar with rare conditions, plus specialists as needed
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with rare disease patient organizations for support
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
How is plague diagnosed?
How is the infection treated?
Do people I live with or have been near need to be checked?

Quick facts

Symptoms usually startany time in life

The infection is caused by a bacterium called Yersinia pestis.

Infectious

Also known as: infection by yersinia pestis; pest; pestilential fever; yersiniosis

Patient organizations

Rare-disease groups that can help

Source: NIH GARD · PlagueGARD ID 18702 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Plague.

Explore the Plague blog

Explore research for Plague

Explore actively recruiting Plague studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Plague with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

Powered by HealthSpark, our AI chat helper

I can help you find recruiting Plague studies. Enter a ZIP code, address or city below and I'll look within 50 miles.

Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

Get Signals for Plague

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HealthStoryfor Plague

Create a living journal that talks back

HealthStory evolves private journaling with a living AI journal that talks back and asks thoughtful questions, helping you capture your Plague experiences more deeply and prepare for better conversations with your doctors and care team.

Start your Plague journal

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