Living with Parkinsonian-pyramidal syndrome
A rare inherited form of Parkinson disease linked to the FBXO7 gene, with movement, muscle, and balance problems.
Understanding Parkinsonian-pyramidal syndrome
It combines Parkinson-like symptoms with signs of changes in the nerve pathways that control muscle movement (pyramidal signs). It tends to start in the teenage years or adulthood.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Parkinson-like symptoms (parkinsonism)
- Stiffness (rigidity)
- Balance problems
- Muscle spasms or stiffness (spasticity)
- Trouble swallowing
- Problems with thinking or sleep
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include brain and nervous system specialists and genetic specialists.
- 3Consider genetic testing
Changes in FBXO7 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Parkinson & Movement Disorder Alliance may keep lists of experts for this condition.
Care & treatment
- Care team
- Brain and nervous system specialists (neurologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Parkinson & Movement Disorder Alliance
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Parkinson & Movement Disorder Alliance
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the FBXO7 gene cause this condition. It is autosomal recessive, which means a child inherits a changed copy of the gene from each parent.
Also known as: autosomal recessive early-onset parkinson disease 15; autosomal recessive early-onset parkinson disease type 15; pallidopyramidal syndrome; parkinson disease 15, autosomal recessive; parkinson disease 15, autosomal recessive early-onset; parkinsonian pyramidal syndrome
Patient organizations
- Parkinson & Movement Disorder AllianceParkinsonism · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Parkinsonian-pyramidal syndrome.
Explore research for Parkinsonian-pyramidal syndrome
Explore actively recruiting Parkinsonian-pyramidal syndrome studies with HealthSpark.
Find actively recruiting studies for Parkinsonian-pyramidal syndrome with HealthSpark. Share your city to explore research near you.
- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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