Living with Palmoplantar keratoderma, nonepidermolytic, focal or diffuse
A genetic skin condition with patches of thick skin on the soles, and sometimes the palms, that can blister painfully.
Understanding Palmoplantar keratoderma, nonepidermolytic, focal or diffuse
The thick skin often shows up in patches on the soles of the feet, and often on the palms too. The nails are little affected or not at all. Painful blisters on the soles are common. GARD lists the onset as childhood.
Signs & symptoms
Symptoms vary from person to person. GARD describes these features:
- Patches of thick skin on the soles
- Thick skin on the palms
- Painful blisters on the soles
- White patches in the mouth (subtle)
- Heavy sweating of the soles (sometimes)
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in KRT6C are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Foundation for Ichthyosis and Related Skin Types may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: Foundation for Ichthyosis and Related Skin Types
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Foundation for Ichthyosis and Related Skin Types and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the KRT6C gene cause this condition. It is autosomal dominant, which means one changed copy of the gene is enough to cause it.
Also known as: autosomal dominant focal non-epidermolytic palmoplantar keratoderma with plantar blistering; palmoplantar keratoderma, focal or diffuse; ppknefd
Patient organizations
- Foundation for Ichthyosis and Related Skin TypesPalmoplantar keratoderma, nonepidermolytic, focal or diffuse · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Palmoplantar keratoderma, nonepidermolytic, focal or diffuse.
Explore research for Palmoplantar keratoderma, nonepidermolytic, focal or diffuse
Explore actively recruiting Palmoplantar keratoderma, nonepidermolytic, focal or diffuse studies with HealthSpark.
Find actively recruiting studies for Palmoplantar keratoderma, nonepidermolytic, focal or diffuse with HealthSpark. Share your city to explore research near you.
- Recruiting studies from ClinicalTrials.gov
- Share your city to look for research near you
- Eligibility is confirmed by the study team
Powered by HealthSpark, our AI chat helper
I can help you find recruiting Palmoplantar keratoderma, nonepidermolytic, focal or diffuse studies. Enter a ZIP code, address or city below and I'll look within 50 miles.
Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
Get Signals for Palmoplantar keratoderma, nonepidermolytic, focal or diffuse
Stay in the loop with community stories and updates from medical researchers.
Create a living journal that talks back
HealthStory evolves private journaling with a living AI journal that talks back and asks thoughtful questions, helping you capture your Palmoplantar keratoderma, nonepidermolytic, focal or diffuse experiences more deeply and prepare for better conversations with your doctors and care team.
Your journal is private. Sharing your story publicly is a separate choice, made with Share your story above.