Living with Palmoplantar keratoderma i, striate, focal, or diffuse
An inherited skin condition that thickens the skin on the palms and soles, often in lines on the fingers.
Understanding Palmoplantar keratoderma i, striate, focal, or diffuse
In the striate form, thick, scaly lines appear on the fingers and palms. The thickening is most common where the skin gets pressure and rubbing. The focal and diffuse forms have also been described.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Thick skin on palms and soles
- Thick, scaly streaks along the fingers onto the palm
- Blisters on the palms and soles
- Heavy sweating (hyperhidrosis)
- Poorly formed or yellow nails
- Nails lifting off the nail bed
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Foundation for Ichthyosis and Related Skin Types may keep lists of experts for this condition.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Expert lists: Foundation for Ichthyosis and Related Skin Types
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Foundation for Ichthyosis and Related Skin Types
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the DSG1 gene cause this condition. It is autosomal dominant, which means one changed copy of the gene is enough to cause it.
Also known as: keratoderma, palmoplantar, striate form i; keratosis palmoplantaris striata i; keratosis palmoplantaris striata i, ad; palmoplantar keratoderma i, focal; palmoplantar keratoderma i, striate or diffuse; striate palmoplantar keratoderma i
Patient organizations
- Foundation for Ichthyosis and Related Skin TypesPalmoplantar keratoderma i, striate, focal, or diffuse · United States
You are more than your diagnosis
Perspectives from people navigating life with Palmoplantar keratoderma i, striate, focal, or diffuse.
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