Living with OSLAM syndrome
A rare genetic condition with bone cancer (osteosarcoma), limb differences, and larger-than-usual red blood cells without anemia.
Understanding OSLAM syndrome
Limb differences include fused forearm bones and curved little fingers, as well as other hand and foot differences. GARD notes there have been no further descriptions in the literature since 1977. GARD lists onset as newborn.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Bone cancer (osteosarcoma)
- Short stature
- Larger-than-usual red blood cells
- Differences in neutrophils (white blood cells)
- Dental cavities
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include bone and joint specialists, cancer specialists and genetic specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- Bone and joint specialists (orthopedists or orthopedic surgeons); Cancer specialists (oncologists); Genetic specialists (geneticists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with rare disease patient organizations for support
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in genes cause this condition. It is inherited in an autosomal dominant way, meaning one changed copy of the gene can be enough.
Also known as: oslam (osteosarcoma, limb anomalies, erythroid macrocytosis) syndrome; osteosarcoma-limb anomalies-erythroid macrocytosis syndrome; osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow; osteosarcoma, limb anomalies, and macrocytosis; osteosarcoma, limb anomalies, erythroid macrocytosis syndrome
Patient organizations
Rare-disease groups that can help
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with OSLAM syndrome.
Explore research for OSLAM syndrome
Explore actively recruiting OSLAM syndrome studies with HealthSpark.
Find actively recruiting studies for OSLAM syndrome with HealthSpark. Share your city to explore research near you.
- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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