Living with Odonto-tricho-ungual-digito-palmar syndrome
A rare genetic condition with teeth at birth, fragile hair and nails, and differences in the hands and feet.
Understanding Odonto-tricho-ungual-digito-palmar syndrome
Babies have teeth at birth (neonatal teeth). Hair is straw-like, discolored, and fragile, and nails are poorly formed. The hands and feet have differences: deep palm creases, short fingers, and very short first hand and foot bones. GARD lists newborn and infant years as the usual onset.
Signs & symptoms
GARD doesn't list specific symptoms for this condition yet. Based on its summary, features may include:
- Teeth present at birth (neonatal teeth)
- Straw-like, discolored, fragile hair
- Poorly formed nails
- Short fingers (brachydactyly)
- Deep palm creases
- Very short first hand and foot bones
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists, gum, teeth and mouth specialists and skin, hair, and nail specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
National Foundation for Ectodermal Dysplasias may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Gum, teeth and mouth specialists (odontologists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: National Foundation for Ectodermal Dysplasias
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Foundation for Ectodermal Dysplasias and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD doesn't describe a cause for this condition yet. It is inherited in an autosomal dominant way, meaning one changed copy of the gene can be enough.
Also known as: odonto-tricho-ungual-digito-palmar syndrome mendoza-valiente type; odonto-tricho-ungual-digito-palmar syndrome, mendoza-valiente type; odontotrichoungual-digital-palmar syndrome; otudp syndrome
Patient organizations
- National Foundation for Ectodermal DysplasiasEctodermal dysplasias · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Odonto-tricho-ungual-digito-palmar syndrome.
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