Living with Odonto-onycho-dermal dysplasia
A rare genetic condition affecting teeth, nails, skin, and sweating, with missing teeth and cone-shaped front teeth.
Understanding Odonto-onycho-dermal dysplasia
Many people have missing baby and adult teeth, with cone-shaped incisors and canines. Nails are poorly formed, and skin on the palms and soles is thick and dry. Hair may be sparse, and sweating may be too high or too low. GARD lists childhood as the usual onset.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Missing adult teeth
- Cone-shaped front teeth
- Dry skin and thick skin on the palms and soles
- Poorly formed or ridged nails
- Sparse scalp hair and eyebrows
- Too little or too much sweating
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists, gum, teeth and mouth specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in WNT10A are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
National Foundation for Ectodermal Dysplasias may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Gum, teeth and mouth specialists (odontologists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: National Foundation for Ectodermal Dysplasias
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Foundation for Ectodermal Dysplasias and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the WNT10A gene cause this condition. It is inherited in an autosomal recessive way, meaning a child inherits a changed copy of the gene from each parent.
Also known as: oodd
Patient organizations
- National Foundation for Ectodermal DysplasiasOdonto-onycho-dermal dysplasia · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Odonto-onycho-dermal dysplasia.
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