Living with Nonsyndromic congenital nail disorder 1
A genetic condition affecting the fingernails and toenails, with thick nails that lift away from the nail bed and look claw-like.
Understanding Nonsyndromic congenital nail disorder 1
Nails are extremely thick (onychauxis), may lift off the nail bed (onycholysis), and can look claw-like. Some fingers and toes may be missing part of the nail. Nails are often abnormal from birth but may not be noticed until later in childhood because they grow slowly. GARD says people have no other health problems related to the condition.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Poorly formed fingernails (nail dysplasia)
- Brittle nails
- Grooved or ridged nails
- Nail pits
- Spoon-shaped nails
- Thin nails
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in FZD6 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Children's Skin Disease Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the FZD6 gene cause this condition. It is inherited in an autosomal dominant way, meaning one changed copy of the gene can be enough.
Also known as: claw-shaped nails; fzd6 inherited isolated nail anomaly; idiopathic trachyonychia; inherited isolated nail anomaly caused by mutation in fzd6; nail disorder, nonsyndromic congenital, 10; nail disorder, nonsyndromic congenital, type 10
Patient organizations
- Children's Skin Disease FoundationSkin diseases · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Nonsyndromic congenital nail disorder 1.
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