Living with Naegeli-Franceschetti-Jadassohn syndrome
A rare skin condition with a net-like pattern of dark skin, thick skin on the palms and soles, and no fingerprints.
Understanding Naegeli-Franceschetti-Jadassohn syndrome
Ectodermal dysplasias affect the skin, hair, nails, teeth, and sweat glands. A common sign is a net-like pattern of dark brown or gray skin on the neck, chest, and belly that appears in infancy or early childhood. It may fade with age. The palms and soles often become thick and hard. Most people lack fingerprints.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Net-like dark skin patterns
- Thick, hard skin on palms and soles
- Brittle or poorly formed nails
- No fingerprints (adermatoglyphia)
- Reduced sweating (hypohidrosis)
- Tooth differences
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in KRT14 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
National Foundation for Ectodermal Dysplasias may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: National Foundation for Ectodermal Dysplasias
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Foundation for Ectodermal Dysplasias and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD lists changes in the KRT14 gene. The condition is autosomal dominant, which means one changed copy of the gene can be enough to cause it.
Also known as: franceschetti-jadassohn syndrome; naegeli syndrome; naegeli's syndrome; nfj syndrome; nfjs
Patient organizations
- National Foundation for Ectodermal DysplasiasNaegeli-Franceschetti-Jadassohn syndrome · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Naegeli-Franceschetti-Jadassohn syndrome.
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