Living with Myeloperoxidase deficiency
A rare immune system condition in which certain white blood cells lack an enzyme; most people have no symptoms.
Understanding Myeloperoxidase deficiency
Myeloperoxidase is an enzyme in white blood cells called neutrophils and monocytes. Most people with this condition have no symptoms. Occasionally, serious infections can happen, especially repeated yeast (candida) infections, which can be worse in people who also have diabetes. It can be found at any time in life.
Signs & symptoms
GARD lists these features as most common:
- Low myeloperoxidase activity in white blood cells
- Immune system differences
- Blood test differences
- Repeated candida (yeast) infections in some people
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include allergy and immune system specialists and genetic specialists.
- 3Consider genetic testing
Changes in MPO are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD lists changes in the MPO gene. A child inherits a changed copy of the gene from each parent (autosomal recessive).
Also known as: mpo - myeloperoxidase deficiency; mpo deficiency; mpod; myeloperoxidase deficiency syndrome
Patient organizations
- Immune Deficiency FoundationPrimary immunodeficiency · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Myeloperoxidase deficiency.
Explore research for Myeloperoxidase deficiency
Explore actively recruiting Myeloperoxidase deficiency studies with HealthSpark.
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- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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