Living with Monoclonal gammopathy of undetermined significance
A condition in which an abnormal protein is found in the blood, which usually causes no problems but is watched over time.
Understanding Monoclonal gammopathy of undetermined significance
MGUS typically does not cause any problems, although some people have numbness, tingling, or weakness. In some cases it may progress over time to certain blood cancers, such as multiple myeloma, macroglobulinemia, or B-cell lymphoma. People with MGUS are usually monitored closely to make sure protein levels do not rise and other problems do not develop.
Signs & symptoms
GARD doesn't list specific symptoms for this condition. Most people have no problems, though some notice numbness, tingling, or weakness.
- Often no symptoms
- Numbness
- Tingling
- Weakness
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Your doctor may refer you to a specialist who knows rare conditions.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- A doctor familiar with rare conditions, plus specialists as needed
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with HealthTree Foundation and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says MGUS is thought to be multifactorial, linked to the effects of multiple genes in combination with lifestyle and environmental factors.
Also known as: asymptomatic monoclonal gammopathy; benign monoclonal gammopathy; mgus; mgus - monoclonal gammopathy of uncertain significance; mgus - monoclonal gammopathy of undetermined significance; monoclonal gammopathy of uncertain significance
Patient organizations
- HealthTree FoundationMonoclonal gammopathy of undetermined significance · United States
- International Myeloma FoundationMonoclonal gammopathy of undetermined significance · United States
You are more than your diagnosis
Perspectives from people navigating life with Monoclonal gammopathy of undetermined significance.
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