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Living with Microsporidiosis

An infection that mainly affects people with weakened immune systems, causing diarrhea and weight loss.

Understanding Microsporidiosis

Microsporidiosis is a fungal infection caused by Microsporidia that occurs in people with weakened immune systems.

It causes diarrhea and weight loss (wasting) in people whose immune systems are weakened (immunocompromised). It can occur at any time in life.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Long-lasting diarrhea
  • Diarrhea that comes and goes
  • Abdominal pain
  • Weight loss
  • Weakened immune function

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Your doctor may refer you to a specialist who knows rare conditions.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
A doctor familiar with rare conditions, plus specialists as needed
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with rare disease patient organizations for support
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
How is this infection diagnosed and treated?
Does my immune condition raise my risk, and how is it managed?
How can I stay hydrated and keep my weight up?

Quick facts

Symptoms usually startany time in life

GARD describes this as an infection caused by Microsporidia, a type of fungus. It occurs in people with weakened immune systems.

Infectious

Also known as: infection by microspora; infection by microsporea; infection by microsporida; infection by microsporidia; infection caused by microspora; infection caused by microsporidia

Patient organizations

Rare-disease groups that can help

Source: NIH GARD · MicrosporidiosisGARD ID 3655 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Microsporidiosis.

Explore the Microsporidiosis blog

Explore research for Microsporidiosis

Explore actively recruiting Microsporidiosis studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Microsporidiosis with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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I can help you find recruiting Microsporidiosis studies. Enter a ZIP code, address or city below and I'll look within 50 miles.

Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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HealthStory evolves private journaling with a living AI journal that talks back and asks thoughtful questions, helping you capture your Microsporidiosis experiences more deeply and prepare for better conversations with your doctors and care team.

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