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Living with Microscopic polyangiitis

A condition that causes inflammation of blood vessels, which can affect organs such as the kidneys, lungs, nerves, skin, and joints.

Understanding Microscopic polyangiitis

Microscopic polyangiitis (MPA) is a condition that causes inflammation of the blood vessels (vasculitis), which can lead to organ damage.

The kidneys, lungs, nerves, skin, and joints are the most commonly affected areas. MPA is diagnosed in people of all ages, all ethnicities, and both sexes. It may begin in childhood or adulthood. GARD says the cause is unknown.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Inflammation of blood vessels (vasculitis)
  • Kidney inflammation (glomerulonephritis)
  • Blood in the urine
  • Coughing up blood
  • Fever and fatigue
  • Joint pain and abdominal pain

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include autoimmune and inflammatory disease specialists, brain and nervous system specialists, kidney specialists and lung and breathing specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Autoimmune Association, Global Autoimmune Institute and Vasculitis Foundation may keep lists of experts for this condition.

Care & treatment

Care team
autoimmune and inflammatory disease specialists (rheumatologists); Brain and nervous system specialists (neurologists); Kidney specialists (nephrologists); Lung and breathing specialists (pulmonologists)
Expert care
Expert lists: Autoimmune Association, Global Autoimmune Institute, Vasculitis Foundation
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Autoimmune Association and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which tests are used to diagnose MPA and check the kidneys and lungs?
Which specialists should be on my care team?
What symptoms should prompt me to call right away?

Quick facts

Symptoms usually startChild and as an Adult

GARD says the cause of this disorder is unknown.

RespiratoryNeurologicalKidney

Also known as: micropolyangiitis; microscopic polyarteritis; mpa; mpa - microscopic polyangiitis

Patient organizations

Source: NIH GARD · Microscopic polyangiitisGARD ID 3652 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Microscopic polyangiitis.

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