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Living with Mesangial proliferative glomerulonephritis

A kidney condition that can cause protein or blood in the urine and swelling.

Understanding Mesangial proliferative glomerulonephritis

Mesangial proliferative glomerulonephritis is a kidney condition with extra cells and damage in the glomeruli, the kidney's filters.

It may show up as nephrotic syndrome, a group of signs including protein in the urine, low blood protein, high cholesterol, and swelling. It can also cause blood in the urine. It can occur in several kidney diseases, most commonly IgA nephropathy, and also IgM nephropathy, lupus nephritis, and C1q nephropathy.

Signs & symptoms

GARD doesn't list a separate symptom list, but its summary describes these:

  • Protein in the urine
  • Blood in the urine
  • Swelling
  • Low blood protein
  • High cholesterol and triglycerides

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Your doctor may refer you to a specialist who knows rare conditions.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    NephCure Kidney International may keep lists of experts for this condition.

Care & treatment

Care team
A doctor familiar with rare conditions, plus specialists as needed
Expert care
Expert lists: NephCure Kidney International
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with National Kidney Foundation and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which underlying kidney disease do I have?
How will my kidney function and protein levels be monitored?
Which specialists, such as nephrologists, should be on my care team?

Quick facts

It may occur in several kidney diseases, such as IgA nephropathy, IgM nephropathy, lupus nephritis, and C1q nephropathy. In some cases the cause is unclear.

Also known as: mesangioproliferative glomerulonephritis

Patient organizations

Source: NIH GARD · Mesangial proliferative glomerulonephritisGARD ID 9580 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Mesangial proliferative glomerulonephritis.

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