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Living with Malignant Sertoli-Leydig cell tumor of ovary

A rare ovarian tumor, usually in young women, that can raise male-type hormone levels.

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Understanding Malignant Sertoli-Leydig cell tumor of ovary

Malignant Sertoli-Leydig cell tumor of ovary is a rare ovarian cancer from the cells that support egg development and make hormones.

It typically occurs in young women, but can occur at a variety of ages. When the tumor makes hormones, it can cause signs of too much male-type hormone (androgen).

Signs & symptoms

GARD doesn't list a separate symptom list, but its summary describes these signs:

  • Extra body or facial hair (hirsutism)
  • Hair loss
  • No periods (amenorrhea)
  • Infrequent periods (oligomenorrhea)

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include cancer specialists, gynecologic cancer specialists, maternal-fetal medicine specialists and women’s reproductive health specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Cancer specialists (oncologists); Gynecologic cancer specialists (gynecologic oncologists); Maternal-fetal medicine specialists (pregnancy-related); Women’s reproductive health specialists (obstetricians / gynecologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with National Ovarian Cancer Coalition and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Is my tumor making hormones, and how will that be tracked?
Which specialists should treat this tumor?
How might treatment affect fertility?

Quick facts

Symptoms usually starta variety of ages

GARD doesn't describe a cause for this condition yet.

Urinary and Reproductive

Also known as: malignant ovarian sertoli-leydig cell tumor; malignant ovarian sertoli-leydig cell tumour; malignant sertoli-leydig cell tumor of the ovary; ovarian malignant sertoli-leydig cell tumor; ovarian malignant sertoli-leydig cell tumour; ovarian sertoli-leydig cell cancer

Patient organizations

Source: NIH GARD · Malignant Sertoli-Leydig cell tumor of ovaryGARD ID 5495 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

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Explore research for Malignant Sertoli-Leydig cell tumor of ovary

Explore actively recruiting Malignant Sertoli-Leydig cell tumor of ovary studies with HealthSpark.

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  • Eligibility is confirmed by the study team

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