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Living with Malignant peritoneal mesothelioma

An aggressive cancer of the lining of the abdomen that usually causes belly pain and fluid buildup.

Understanding Malignant peritoneal mesothelioma

Malignant peritoneal mesothelioma is an aggressive cancer that starts in the peritoneum, the lining of the abdomen.

People usually come to care with abdominal pain and fluid in the belly (ascites). It is described in adults.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Abdominal pain
  • Bloated belly
  • Fluid buildup in the belly (ascites)
  • Inflamed abdominal lining (peritonitis)
  • Weight loss

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include cancer specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Mesothelioma.net may keep lists of experts for this condition.

Care & treatment

Care team
Cancer specialists (oncologists)
Expert care
Expert lists: Mesothelioma.net
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Mesothelioma.net and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
What tests will confirm the type and extent of the cancer?
How can the belly fluid and pain be managed?
Which specialists should be on my care team?

Quick facts

Symptoms usually startAdult

GARD doesn't describe a cause for this condition yet.

Also known as: advanced malignant mesothelioma of peritoneum; advanced malignant mesothelioma of the peritoneum; advanced malignant peritoneal mesothelioma; advanced peritoneal malignant mesothelioma; cancer of the peritoneum, mesothelioma; diffuse malignant peritoneal mesothelioma

Patient organizations

Source: NIH GARD · Malignant peritoneal mesotheliomaGARD ID 20102 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Malignant peritoneal mesothelioma.

Explore the Malignant peritoneal mesothelioma blog

Explore research for Malignant peritoneal mesothelioma

Explore actively recruiting Malignant peritoneal mesothelioma studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Malignant peritoneal mesothelioma with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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