Living with Liddle syndrome
An inherited form of high blood pressure that begins unusually early in life and can lower potassium levels.
Understanding Liddle syndrome
The high blood pressure is severe and begins unusually early, often in childhood, though some people are not diagnosed until adulthood. Some people have no other signs, especially in childhood. Low potassium in the blood (hypokalemia) can also occur.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- High blood pressure
- Muscle weakness or pain
- Tiredness (fatigue)
- Constipation
- Irregular heartbeat or palpitations
- Kidney problems
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and kidney specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- Genetic specialists (geneticists); Kidney specialists (nephrologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Kidney Foundation and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is inherited in an autosomal dominant way, which means one changed copy of a gene is enough. GARD does not name a gene.
Also known as: liddle's syndrome; pseudoaldosteronism; pseudohyperaldosteronism type 1; pseudoprimary hyperaldosteronism
Patient organizations
- National Kidney FoundationKidney diseases · United States
- Renal Support NetworkKidney diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Liddle syndrome.
Explore research for Liddle syndrome
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- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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