Living with Insulin-resistance syndrome type B
A rare condition in which antibodies block the insulin receptor, causing extreme insulin resistance.
Understanding Insulin-resistance syndrome type B
It belongs to the group of extreme insulin-resistance syndromes. It can start at a variety of ages.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Body doesn't respond well to insulin (insulin resistance)
- Abnormal glucose tolerance
- Darkened, thickened skin (acanthosis nigricans)
- Autoimmunity
- Changes in body weight
- Abnormal leptin levels
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and hormone specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- Genetic specialists (geneticists); Hormone specialists (endocrinologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with rare disease patient organizations for support
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Autoantibodies, which are antibodies against the body's own tissue, block the insulin receptor. GARD doesn't list a gene.
Also known as: insulin resistance - type b
Patient organizations
Rare-disease groups that can help
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Insulin-resistance syndrome type B.
Explore research for Insulin-resistance syndrome type B
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Find actively recruiting studies for Insulin-resistance syndrome type B with HealthSpark. Share your city to explore research near you.
- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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