Living with Infertility associated with multi-tailed spermatozoa and excessive DNA
A condition affecting only males, with large, misshapen sperm with multiple tails that cause infertility.
Understanding Infertility associated with multi-tailed spermatozoa and excessive DNA
Almost all sperm cells have abnormally large, misshapen heads with extra chromosomes, usually four copies of each instead of one. They usually have multiple tails, most often four. Because of the extra genetic material, these sperm are unable to lead to a healthy pregnancy.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Infertility in males
- Sperm with large, misshapen heads (macrozoospermia)
- Sperm with several tails
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and urinary and male reproductive system specialists.
- 3Consider genetic testing
Changes in AURKC are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Resolve: The National Infertility Association may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Urinary and male reproductive system specialists (urologists)
- Expert care
- Expert lists: Resolve: The National Infertility Association
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Resolve: The National Infertility Association
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the AURKC gene cause this condition. It is inherited in an autosomal recessive pattern, meaning a person inherits a changed copy of the gene from each parent.
Also known as: infertility associated with multi-tailed spermatozoa and excessive deoxyribonucleic acid; macrocephalic sperm head syndrome; macrozoospermia with multiflagellar polyploid spermatozoa; male infertility due to large-headed multiflagellar polyploid spermatozoa; male infertility due to macrozoospermia; male infertility with large-headed, multiflagellar, polyploid spermatozoa
Patient organizations
- Resolve: The National Infertility AssociationInfertility · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
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