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Living with Immunodeficiency 79

A mild inherited immune condition with stubborn skin warts from childhood and sometimes repeated respiratory infections.

Understanding Immunodeficiency 79

Immunodeficiency 79 is an inherited immune disorder that causes repeated, hard-to-treat skin warts from childhood due to uncontrolled human papillomavirus (HPV) infection.

Some people also have repeated respiratory infections starting in childhood. Overall it is mild compared with other primary immune deficiencies, and people may not come to attention until adulthood. Lab tests show no CD4 protein on certain immune cells.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Widespread skin warts
  • Warts on the palms
  • Warts on the soles
  • Repeated colds
  • Repeated middle ear infections
  • Low CD4+ T cell proportion

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Your doctor may refer you to a specialist who knows rare conditions.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Immune Deficiency Foundation may keep lists of experts for this condition.

Care & treatment

Care team
A doctor familiar with rare conditions, plus specialists as needed
Expert care
Expert lists: Immune Deficiency Foundation
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Immune Deficiency Foundation
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
How can stubborn warts be treated?
Which immune lab tests confirm this condition?
How are respiratory infections monitored?

Quick facts

InheritanceAutosomal Recessive

GARD describes this as an autosomal recessive disorder, meaning a child inherits a changed copy of the gene from each parent. It doesn't name a gene.

Also known as: cd4 deficiency; imd79

Patient organizations

Source: NIH GARD · Immunodeficiency 79GARD ID 9523 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Immunodeficiency 79.

Explore the Immunodeficiency 79 blog

Explore research for Immunodeficiency 79

Explore actively recruiting Immunodeficiency 79 studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Immunodeficiency 79 with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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