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Living with Histoplasmosis

A rare fungal infection that mainly affects the lungs after breathing in spores, from mild flu-like illness to serious disease.

Understanding Histoplasmosis

Histoplasmosis is a rare fungal infection that mainly affects the lungs.

It starts after a person breathes in spores of a fungus called Histoplasma capsulatum. How serious it is depends on the person's immune system and how many spores they breathe in. In people with healthy immune systems, it is usually mild or without symptoms. In people with weakened immune systems, it can spread to several organs.

Signs & symptoms

Symptoms vary from person to person. GARD's summary describes:

  • Mild, flu-like illness
  • No symptoms in some people
  • Fever
  • Pneumonia
  • Enlarged liver and spleen
  • Skin changes

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Your doctor may refer you to a specialist who knows rare conditions.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
A doctor familiar with rare conditions, plus specialists as needed
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with American Lung Association
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Does my immune system raise my risk of spreading?
What tests confirm histoplasmosis?
What signs mean I should call you right away?

Quick facts

It is caused by breathing in spores of the fungus Histoplasma capsulatum.

Infectious

Also known as: darling disease; histoplasma caused disease or disorder; histoplasma disease or disorder; histoplasma infectious disease

Patient organizations

Source: NIH GARD · HistoplasmosisGARD ID 18692 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Histoplasmosis.

Explore the Histoplasmosis blog

Explore research for Histoplasmosis

Explore actively recruiting Histoplasmosis studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Histoplasmosis with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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