Living with Hereditary spastic paraplegia 25
A rare, complex type of hereditary spastic paraplegia that starts in adulthood, with back and neck pain from disc problems.
Understanding Hereditary spastic paraplegia 25
It brings stiff, weak legs along with spinal pain that spreads to the arms or legs and is related to disc herniation, plus mild nerve damage affecting feeling and movement. GARD says it was mapped to chromosome 6q23-q24.1.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Stiff legs (spastic paraplegia)
- Partial leg weakness
- Disc herniation
- Neck pain
- Leg pain
- Nerve damage affecting feeling
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include brain and nervous system specialists and genetic specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Spastic Paraplegia Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Brain and nervous system specialists (neurologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Spastic Paraplegia Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Spastic Paraplegia Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD links it to a region on chromosome 6q23-q24.1 and doesn't name a gene. It is autosomal recessive, so a child inherits a changed copy of the gene from each parent.
Also known as: autosomal recessive spastic paraplegia 25; autosomal recessive spastic paraplegia disc herniation syndrome; autosomal recessive spastic paraplegia type 25; autosomal recessive spastic paraplegia-disc herniation syndrome; disc herniation with spastic paraplegia, autosomal recessive; hereditary spastic paraplegia type 25
Patient organizations
- Spastic Paraplegia FoundationHereditary spastic paraplegia · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Hereditary spastic paraplegia 25.
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