Living with Hereditary sensory and autonomic neuropathy type 2
An inherited nerve condition in which the ability to feel pain and temperature is lost, starting in infancy or early childhood.
Understanding Hereditary sensory and autonomic neuropathy type 2
It usually starts in infancy or early childhood with numbness in the hands and feet, followed by the loss of pain and temperature sensing. Unnoticed injuries can lead to open sores, infections, and joint damage (Charcot joints). People may injure themselves by biting the tongue, lips, or fingers. Effects on the automatic nervous system vary.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Numbness in the hands and feet
- Loss of pain and temperature sense
- Sores on the hands and feet
- Excessive sweating
- Bone and joint changes
- Poorly formed fingernails and toenails
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include brain and nervous system specialists and genetic specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
The Foundation for Peripheral Neuropathy may keep lists of experts for this condition.
Care & treatment
- Care team
- Brain and nervous system specialists (neurologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: The Foundation for Peripheral Neuropathy
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with The Foundation for Peripheral Neuropathy and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in genes (also called variants) cause this condition. It is autosomal recessive, so a child inherits a changed copy of the gene from each parent.
Also known as: autosomal recessive sensory radicular neuropathy; dominant hereditary sensory neuropathy, type ii; hereditary sensory and autonomic neuropathy type ii; hereditary sensory and autonomic neuropathy, type ii; hereditary sensory neuropathy type 2; hsan2
Patient organizations
- The Foundation for Peripheral NeuropathyPeripheral neuropathy · United States
- Neuropathy Action FoundationPeripheral neuropathy · United States
You are more than your diagnosis
Perspectives from people navigating life with Hereditary sensory and autonomic neuropathy type 2.
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