Living with Hereditary fructosuria
A condition in which the body cannot digest the sugar fructose, causing stomach upset and low blood sugar.
Understanding Hereditary fructosuria
Fructose is a simple sugar found mostly in fruit. Symptoms start in infancy when fruits, juices, or other foods with fructose are first introduced. Repeated fructose can lead to liver and kidney damage. Many people come to dislike fruits and juices. GARD says it should not be confused with fructose malabsorption.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Belly pain
- Nausea and vomiting
- Bloating
- Diarrhea
- Low blood sugar (hypoglycemia)
- Slow growth and weight gain
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include digestive system specialists, genetic specialists and kidney specialists.
- 3Consider genetic testing
Changes in ALDOB are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
Care & treatment
- Care team
- Digestive system specialists (gastroenterologists); Genetic specialists (geneticists); Kidney specialists (nephrologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with National Kidney Foundation and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by changes in the ALDOB gene. It is autosomal recessive, so a child inherits a changed copy of the gene from each parent.
Also known as: aldb - aldolase b deficiency; aldb deficiency; aldob deficiency; aldolase b deficiency; fructosaemia; fructose intolerance
Patient organizations
- National Kidney FoundationKidney diseases · United States
- Renal Support NetworkKidney diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Hereditary fructosuria.
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