Living with Hereditary diffuse gastric adenocarcinoma
An inherited condition that raises the chance of a certain kind of stomach cancer, and of lobular breast cancer in women.
Understanding Hereditary diffuse gastric adenocarcinoma
Women with HDGC also have a higher risk of lobular breast cancer. Cancers tied to HDGC generally occur at younger ages than in people without an inherited risk. Diagnosis is based on symptoms and family history and can be confirmed by genetic testing. It affects adults.
Signs & symptoms
GARD doesn't list specific symptoms for this condition yet.
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include cancer specialists, digestive system specialists and genetic specialists.
- 3Consider genetic testing
Changes in CDH1 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
FORCE: Facing Our Risk of Cancer Empowered may keep lists of experts for this condition.
Care & treatment
- Care team
- Cancer specialists (oncologists); Digestive system specialists (gastroenterologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: FORCE: Facing Our Risk of Cancer Empowered
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with FORCE: Facing Our Risk of Cancer Empowered and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by changes in the CDH1 gene and the CTNNA1 gene. It is autosomal dominant, so one changed copy of the gene is enough to raise risk.
Also known as: diffuse gastric and lobular breast cancer syndrome; familial diffuse cancer of stomach; familial diffuse gastric cancer; fdgc; hdgc; hereditary diffuse cancer of stomach
Patient organizations
- FORCE: Facing Our Risk of Cancer EmpoweredHereditary diffuse gastric adenocarcinoma · United States
- No Stomach For CancerHereditary diffuse gastric adenocarcinoma · United States
- American Cancer SocietyHereditary diffuse gastric adenocarcinoma · United States
- Cancer Hope NetworkHereditary diffuse gastric adenocarcinoma · United States
You are more than your diagnosis
Perspectives from people navigating life with Hereditary diffuse gastric adenocarcinoma.
Explore research for Hereditary diffuse gastric adenocarcinoma
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- Recruiting studies from ClinicalTrials.gov
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- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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