Living with Glucocorticoid-remediable aldosteronism
An inherited condition in which the adrenal glands make too much aldosterone, causing high blood pressure.
Understanding Glucocorticoid-remediable aldosteronism
Aldosterone is a hormone made by the adrenal glands that helps the body keep water and sodium and get rid of potassium. People with this condition are also at increased risk for a type of stroke called hemorrhagic stroke. It usually shows up from childhood to adulthood.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- High blood pressure (hypertension)
- Abnormal renin levels
- Enlarged adrenal glands
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists, hormone specialists and kidney specialists.
- 3Consider genetic testing
Changes in CYP11B1 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Primary Aldosteronism Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Hormone specialists (endocrinologists); Kidney specialists (nephrologists)
- Expert care
- Expert lists: Primary Aldosteronism Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Primary Aldosteronism Foundation and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
It is caused by a fusion of the CYP11B1 and CYP11B2 genes and is inherited in an autosomal dominant way, which means one changed copy is enough.
Also known as: acth-dependent hyperaldosteronism syndrome; aldosteronism, glucocorticoid-remediable; aldosteronism, sensitive to dexamethasone; dexamethasone-sensitive hypertension; familial hyperaldosteronism type 1; familial hyperaldosteronism type i
Patient organizations
- Primary Aldosteronism FoundationGlucocorticoid-remediable aldosteronism · United States
- National Kidney FoundationKidney diseases · United States
- Renal Support NetworkKidney diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Glucocorticoid-remediable aldosteronism.
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