Living with Familial adenomatous polyposis 3
An inherited condition with polyps in the digestive tract and a higher chance of colorectal and other cancers.
Understanding Familial adenomatous polyposis 3
It also raises the chance of multiple polyps in the digestive tract. Other cancers reported include endometrial, cervical, and bladder cancer, and also brain, skin (basal cell), and blood cancers. Cancers most often occur in middle age or later.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Several polyps in the colon
- Colon or rectal cancer
- Breast cancer
- Womb lining (endometrial) cancer
- Bladder tumors
- Meningioma (a brain-covering tumor)
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include cancer specialists, digestive system specialists and genetic specialists.
- 3Consider genetic testing
Changes in NTHL1 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
FORCE: Facing Our Risk of Cancer Empowered may keep lists of experts for this condition.
Care & treatment
- Care team
- Cancer specialists (oncologists); Digestive system specialists (gastroenterologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: FORCE: Facing Our Risk of Cancer Empowered
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with FORCE: Facing Our Risk of Cancer Empowered
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the NTHL1 gene cause this condition. It is autosomal recessive, which means two changed copies of the gene are needed, one from each parent.
Also known as: familial adenomatous polyposis type 3; fap3; nthl1-related adenomatous polyposis and colorectal cancer; nthl1-related afap; nthl1-related attenuated familial adenomatous polyposis; nthl1-related attenuated fap
Patient organizations
- FORCE: Facing Our Risk of Cancer EmpoweredFamilial adenomatous polyposis 3 · United States
You are more than your diagnosis
Perspectives from people navigating life with Familial adenomatous polyposis 3.
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