Living with Epidermolysis bullosa simplex with migratory circinate erythema
A rare inherited form of EB simplex with belt-like red areas and small blisters, starting at birth.
Understanding Epidermolysis bullosa simplex with migratory circinate erythema
The red areas have small blisters along the advancing edge. They appear on the arms, legs, and trunk and heal with brown skin color but no scarring. Other body systems are not affected. It usually starts at birth.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Skin blisters
- Belt-like moving red patches
- Blisters on the hands and feet
- Itching
- Darker skin patches after healing
- Fragile skin without scarring
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in KRT5 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
DEBRA of America may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: DEBRA of America
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with DEBRA of America and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the KRT5 gene cause this condition. It is autosomal dominant, which means a change in one copy of the gene can cause it.
Also known as: ebs with circinate migratory erythema; ebs-migr; epidermolysis bullosa simplex 2e, with migratory circinate erythema; epidermolysis bullosa simplex with circinate migratory erythema
Patient organizations
- DEBRA of AmericaEpidermolysis bullosa simplex with migratory circinate erythema · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Epidermolysis bullosa simplex with migratory circinate erythema.
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