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Living with Eosinophilic cellulitis

A rare skin condition (Wells syndrome) with itchy, red, swollen skin patches.

Understanding Eosinophilic cellulitis

Eosinophilic cellulitis (Wells syndrome) is a rare condition that mainly affects the skin.

People often get a skin rash that is first preceded by itching or burning. The rash has raised, red, swollen areas that may feel warm. It is seen in adults. GARD notes that fever and joint pain are less common.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Itching (pruritus)
  • Skin blisters
  • Small fluid-filled skin bumps (vesicles)
  • Swelling (edema)
  • High eosinophil count in the blood

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include skin, hair, and nail specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

  4. Connect with expert centers

    Autoimmune Association may keep lists of experts for this condition.

Care & treatment

Care team
Skin, hair, and nail specialists (dermatologists)
Expert care
Expert lists: Autoimmune Association
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with Autoimmune Association and other patient organizations
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
Which tests or skin biopsy can confirm this diagnosis?
What can ease the itching and swelling?
What might trigger a rash to come back?

Quick facts

Symptoms usually startAdult

GARD says the exact cause is unknown.

Skin

Also known as: familial eosinophilic cellulitis; wells syndrome; wells' syndrome

Patient organizations

Source: NIH GARD · Eosinophilic cellulitisGARD ID 329 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Eosinophilic cellulitis.

Explore the Eosinophilic cellulitis blog

Explore research for Eosinophilic cellulitis

Explore actively recruiting Eosinophilic cellulitis studies with HealthSpark.

HealthSpark

Find actively recruiting studies for Eosinophilic cellulitis with HealthSpark. Share your city to explore research near you.

  • Recruiting studies from ClinicalTrials.gov
  • Share your city to look for research near you
  • Eligibility is confirmed by the study team

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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.

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