Living with Diffuse nonepidermolytic palmoplantar keratoderma
A skin condition causing thick, yellowish skin on the palms and soles that starts in early childhood.
Understanding Diffuse nonepidermolytic palmoplantar keratoderma
It usually begins in early childhood with red palms and soles. The skin gradually thickens and looks yellowish and waxy. Increased sweating is common, along with a tendency toward fungal and bacterial foot infections. It usually does not spread beyond the hands and feet but can affect knuckle pads and nails.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Thick skin on palms and soles
- Redness of the skin
- Dry skin
- Fungal nail infection
- Increased sweating
- Foot infections
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include genetic specialists and skin, hair, and nail specialists.
- 3Consider genetic testing
Changes in KRT1 are linked to this condition. Genetic testing and counseling can help confirm a diagnosis and explain what it means for your family.
- 4Connect with expert centers
Foundation for Ichthyosis and Related Skin Types may keep lists of experts for this condition.
Care & treatment
- Care team
- Genetic specialists (geneticists); Skin, hair, and nail specialists (dermatologists)
- Expert care
- Expert lists: Foundation for Ichthyosis and Related Skin Types
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Foundation for Ichthyosis and Related Skin Types and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
Changes in the KRT1 gene cause this condition. It is autosomal dominant, so a changed copy of the gene from one parent can be enough.
Also known as: diffuse palmoplantar keratoderma, bothnian type; krt1-related diffuse nonepidermolytic keratoderma; neppk; non-epidermolytic palmoplantar keratoderma; nonepidermolytic palmoplantar hyperkeratosis; nonepidermolytic palmoplantar keratoderma
Patient organizations
- Foundation for Ichthyosis and Related Skin TypesDiffuse nonepidermolytic palmoplantar keratoderma · United States
- Children's Skin Disease FoundationSkin diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Diffuse nonepidermolytic palmoplantar keratoderma.
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