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Living with Dextro-looped transposition of the great arteries

A heart condition present from birth in which the two main arteries of the heart are switched.

Understanding Dextro-looped transposition of the great arteries

Dextro-looped transposition of the great arteries, also called complete transposition, is a heart problem some people are born with.

The two main arteries of the heart are switched, which can cause problems with blood flow. GARD lists onset during pregnancy, at birth, or in infancy.

Signs & symptoms

Symptoms vary from person to person. GARD lists these among the most common:

  • Switched main heart arteries
  • Hole in the wall between the heart's upper chambers
  • Differences in the aortic arch
  • Differences in the coronary arteries
  • Differences in the heart valves
  • Problems with blood circulation

Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.

Diagnosis

  1. Talk with your doctor

    Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.

  2. See a specialist

    Specialists who may be involved include genetic specialists and heart and blood vessel specialists.

  3. Ask which tests can help

    Your care team will decide which exams and tests can confirm the diagnosis.

Care & treatment

Care team
Genetic specialists (geneticists); Heart and blood vessel specialists (cardiologists)
Expert care
Ask about multidisciplinary care centers for rare conditions
Treatment
GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
Research
Clinical trials and observational studies may be options. See the research section below.

General information, not medical advice. Your care team makes the decisions.

Everyday life

Living with a rare condition is easier with support.

  • Connect with rare disease patient organizations for support
  • Keep notes on symptoms, changes and questions for appointments
  • Ask about patient registries that help research
  • Look into financial aid and travel resources for care visits
Bring these questions to your next doctor visit
What surgery or procedures are options?
Which specialists, such as pediatric cardiology, should follow my child?
How often will heart scans be needed?

Quick facts

Symptoms usually startduring Pregnancy, at Birth, and as an Infant

GARD says changes in genes cause this condition. It doesn't list a specific gene or inheritance pattern.

Genetic

Also known as: congenitally uncorrected transposition of the great arteries; congenitally uncorrected transposition of the great vessels; d-loop transposition of the great arteries; d-tga; dextrotransposition of the great arteries; dtga

Patient organizations

Rare-disease groups that can help

Source: NIH GARD · Dextro-looped transposition of the great arteriesGARD ID 5476 · GARD page updated September 2026 · Plain-language summary by Know Rare; editorial review pending. General information, not medical advice.

You are more than your diagnosis

Perspectives from people navigating life with Dextro-looped transposition of the great arteries.

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