Living with Dent disease
A long-term kidney condition that mostly affects males, causing protein in the urine and kidney stones.
Understanding Dent disease
Signs appear in early childhood and worsen over time. The most common sign is a large amount of protein in the urine. Other signs include extra calcium in the urine, calcium deposits in the kidneys, and kidney stones. Some people develop rickets, a bone condition.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Large amounts of protein in the urine
- Kidney stones
- Blood in the urine
- Abdominal pain
- Bone pain
- Long-term kidney disease
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include bone and joint specialists, genetic specialists, hormone specialists and kidney specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
Care & treatment
- Care team
- Bone and joint specialists (orthopedists or orthopedic surgeons); Genetic specialists (geneticists); Hormone specialists (endocrinologists); Kidney specialists (nephrologists)
- Expert care
- Ask about multidisciplinary care centers for rare conditions
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Dent Disease Foundation and other patient organizations
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD doesn't name a gene. It lists X-linked inheritance, meaning the gene is on the X chromosome.
Also known as: dent syndrome; dent's disease; low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis; renal fanconi syndrome with nephrocalcinosis and renal stones; x-linked recessive hypercalciuric hypophosphatemic rickets; x-linked recessive hypophosphatemic rickets
Patient organizations
- Dent Disease FoundationDent disease · United States
- American Association of Kidney PatientsDent disease · United States
- National Kidney FoundationKidney diseases · United States
- Renal Support NetworkKidney diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Dent disease.
Explore research for Dent disease
Explore actively recruiting Dent disease studies with HealthSpark.
Find actively recruiting studies for Dent disease with HealthSpark. Share your city to explore research near you.
- Recruiting studies from ClinicalTrials.gov
- Share your city to look for research near you
- Eligibility is confirmed by the study team
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Powered by HealthSpark, our AI chat helper · Study information from ClinicalTrials.gov · Eligibility is confirmed by the study team.
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