Living with Decreased circulating level of specific antibody
A rare immune condition causing repeated ear, sinus, and breathing infections.
Understanding Decreased circulating level of specific antibody
It is a primary immunodeficiency (a condition present from birth). Immunoglobulin levels, including IgG subclasses, are normal. But the body does not respond well to polysaccharides, a type of sugar coating on some germs. GARD lists onset from childhood to adulthood.
Signs & symptoms
Symptoms vary from person to person. GARD lists these among the most common:
- Repeated upper breathing infections
- Repeated upper and lower breathing infections
- Middle ear infections
- Sinus inflammation (sinusitis)
- Nasal inflammation (rhinitis)
- Fewer memory B cells
Not everyone has every symptom. GARD's list comes from the Human Phenotype Ontology.
Diagnosis
- 1Talk with your doctor
Share the symptoms you've noticed, when they started and your family health history. Notes and photos can help.
- 2See a specialist
Specialists who may be involved include allergy and immune system specialists and genetic specialists.
- 3Ask which tests can help
Your care team will decide which exams and tests can confirm the diagnosis.
- 4Connect with expert centers
Immune Deficiency Foundation may keep lists of experts for this condition.
Care & treatment
- Care team
- Allergy and immune system specialists (allergists / immunologists); Genetic specialists (geneticists)
- Expert care
- Expert lists: Immune Deficiency Foundation
- Treatment
- GARD doesn't list specific treatments for this condition. Your care team will tailor care to your symptoms.
- Research
- Clinical trials and observational studies may be options. See the research section below.
General information, not medical advice. Your care team makes the decisions.
Everyday life
Living with a rare condition is easier with support.
- Connect with Immune Deficiency Foundation
- Keep notes on symptoms, changes and questions for appointments
- Ask about patient registries that help research
- Look into financial aid and travel resources for care visits
Quick facts
GARD says changes in genes cause this condition. It doesn't list a specific gene or inheritance pattern.
Also known as: abnormal specific antibody response; decreased specific antibody in blood; immunodeficiency due to selective anti-polysaccharide antibody deficiency; specific anti-polysaccharide antibody deficiency; specific antibody deficiency
Patient organizations
- Immune Deficiency FoundationPrimary immunodeficiency · United States
Broader rare-disease groups
- Global GenesRare Diseases · United States
- National Organization for Rare DisordersRare Diseases · United States
- Genetic AllianceRare Diseases · United States
- RARE FoundationRare Diseases · United States
You are more than your diagnosis
Perspectives from people navigating life with Decreased circulating level of specific antibody.
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